A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome
نویسندگان
چکیده
منابع مشابه
A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome
Idiopathic nephrotic syndrome (NS) is the most common glomerular disorder of childhood. Response to initial treatment with corticosteroids is an indicator of prognosis, as resistant patients often present more progressive disease. In this cross-sectional pilot study, we set out to discover a panel of noninvasive biomarkers that could distinguish steroid-resistant nephrotic syndrome (SRNS) from ...
متن کاملChildhood Idiopathic Steroid Resistant Nephrotic Syndrome, Different Drugs And Outcome.
BACKGROUND The management of steroid resistant nephrotic syndrome (SRNS) is quite difficult in paediatric patients. Not only the remission is difficult but also these patients are at risk of progression to end stage renal disease (ESRD). The goal of treatment is either to achieve complete remission or even partial remission as it is the most important predictor of disease outcome. METHODS Thi...
متن کاملMicroRNAs in idiopathic childhood nephrotic syndrome.
Childhood nephrotic syndrome (NS) is associated with an increase in the permeability across the glomerular filtration barrier due to processes that affect the dynamics and permselectivity of the glomerular filtration barrier. This increased permeability leads to an inability to restrict the loss of protein to 100 mg/m body surface per day (1 ). The incidence of idiopathic NS has been reported t...
متن کاملUnanswered questions in childhood idiopathic nephrotic syndrome
Editorial Implication for health policy/practice/research/medical education: Recent advances in molecular genetics have helped in unraveling the genetic component of idiopathic nephrotic syndrome in children. Similar advances in understanding the environmental triggers and immune defects will help better understand the pathogenesis of the disease. It is hoped that the above advancements will ul...
متن کاملsteroid-responsive nephrotic syndrome of childhood
Cyclophosphamide has been shown to be effective in preventing relapse of steroid-responsive nephrotic syndrome of childhood (Barratt and Soothill, 1970). However, a similar significant effect was not observed by Abramowicz et al. (1970), in a doubleblind trial of azathioprine. This drug was administered in a dosage of 60 mg/M2 surface area per day for 6 months to steroid-responsive nephrotic ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomarker Insights
سال: 2017
ISSN: 1177-2719,1177-2719
DOI: 10.1177/1177271917695832